Postdoctoral fellow (f/m) for biological image-based high-content screening on cell non-autonomous protein aggregate induction, Germany

Description

The DZNE is a center of excellence within the Helmholtz Association that performs translational research on Neurodegenerative Diseases. The center includes eight high-performing sites in Bonn, Dresden, Goettingen, Magdeburg, Munich, Rostock/Greifswald, Tuebingen and Witten.

Our laboratory studies basic mechanisms of prion formation and transmission. We are especially interested in cell non-autonomous aggregate induction, a mechanism of aggregate formation that might also be of importance to other neurodegenerative diseases such as Parkinson’s disease (Krammer et al., Prion 2009; Krammer et al., PNAS 2009). To unravel basic mechanisms of intercellular protein aggregate transmission and spreading, we will perform automated cell-based RNA interference and small molecule screens.


Eligibility

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We are looking for a postdoctoral fellow with excellent analytical and organizational skills and a strong interest in automated high resolution microscopy and image analysis.
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The successful applicant should hold a Ph.D. in cell biology, biotechnology, biochemistry, bioinformatics or related fields. Hands-on experience with liquid handling workstations, liquid dispensers, plate readers and automation scheduling software is preferred.
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Experience in cell-based screening assays, ideally in high-content screening and image analysis would be an advantage.
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The candidate should be able to work independently and have excellent team working skills.
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The candidate will very closely collaborate with the DZNE facilities „Laboratory Automation Technologies“ and „Image Data Analysis“ and with collaborators within the Helmholtz Association.
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Fluency in English is required. The DZNE Bonn offers a cutting-edge infrastructure, an international environment and excellent working conditions.

Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TvöD). The job location is Bonn. The position is available immediately for 2 years with the possibility of an extension. The DZNE seeks to increase the number of female personnel in those areas where they are underrepresented and therefore explicitly encourages women to apply. The DZNE is committed to employing more disabled individuals and especially encourages them to apply.


How to Apply

Interested candidates should send their applications including a CV, a list of publications, a summary of research interests and names and contact details of three referees to Christina Graf, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V., Holbeinstraße 13-15, 53175 Bonn or as a single file to application(at)dzne.de. For further details please contact Dr. Ina Vorberg at ina.vorberg(at)dzne.de or by phone (+49 228 43302-560)


Scholarships deadline

30 September 2011

Scholarships details of Postdoctoral fellow (f/m) for biological image-based high-content screening on cell non-autonomous protein aggregate induction

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